Aurora kinase inhibitor-2


Catalog No. Size PriceQuantity
M14606-2 2mg solid $325
M14606-10 10mg solid $1,300

Description

Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively.

Product information

CAS Number: 331770-21-9

Molecular Weight: 400.43

Formula: C23H20N4O3

Chemical Name: N-{4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl}benzamide

Smiles: COC1=CC2=NC=NC(NC3C=CC(=CC=3)NC(=O)C3C=CC=CC=3)=C2C=C1OC

InChiKey: IMYVCWQAHSYYOO-UHFFFAOYSA-N

InChi: InChI=1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-8-10-17(11-9-16)27-23(28)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Aurora kinase inhibitor-2 (Compound 1) shows excellent levels of Aurora A enzyme inhibition and is also effective in an MCF7 cellular anti-proliferative assay (IC50 value of 1.25 µM).

References:

  1. Andrew A Mortlock, et al. Progress in the development of selective inhibitors of aurora kinases. Curr Top Med Chem. 2005;5(8):807-21.
  2. Nicola M Heron, et al. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1320-3.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed