Description
Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively.
Product information
CAS Number: 331770-21-9
Molecular Weight: 400.43
Formula: C23H20N4O3
Chemical Name: N-{4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenyl}benzamide
Smiles: COC1=CC2=NC=NC(NC3C=CC(=CC=3)NC(=O)C3C=CC=CC=3)=C2C=C1OC
InChiKey: IMYVCWQAHSYYOO-UHFFFAOYSA-N
InChi: InChI=1S/C23H20N4O3/c1-29-20-12-18-19(13-21(20)30-2)24-14-25-22(18)26-16-8-10-17(11-9-16)27-23(28)15-6-4-3-5-7-15/h3-14H,1-2H3,(H,27,28)(H,24,25,26)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Aurora kinase inhibitor-2 (Compound 1) shows excellent levels of Aurora A enzyme inhibition and is also effective in an MCF7 cellular anti-proliferative assay (IC50 value of 1.25 µM).
References:
- Andrew A Mortlock, et al. Progress in the development of selective inhibitors of aurora kinases. Curr Top Med Chem. 2005;5(8):807-21.
- Nicola M Heron, et al. SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1320-3.
Products are for research use only. Not for human use.
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