EGFR/ErbB-2/ErbB-4 inhibitor-2


Catalog No. Size PriceQuantity
M14718-2 2mg solid $325
M14718-10 10mg solid $1,300

Description

EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) is a EGFR and ErbB inhibitor with IC50s of 0.017 μM, 0.08 μM, 1.91 μM.

Product information

CAS Number: 179248-61-4

Molecular Weight: 387.43

Formula: C23H21N3O3

Chemical Name: N-[4-(benzyloxy)phenyl]-6,7-dimethoxyquinazolin-4-amine

Smiles: COC1=CC2=NC=NC(NC3C=CC(=CC=3)OCC3C=CC=CC=3)=C2C=C1OC

InChiKey: DNOKYISWMVFYFA-UHFFFAOYSA-N

InChi: InChI=1S/C23H21N3O3/c1-27-21-12-19-20(13-22(21)28-2)24-15-25-23(19)26-17-8-10-18(11-9-17)29-14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,24,25,26)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

EGFR/ErbB-2/ErbB-4 inhibitor-2 (Compound 5) also inhibits c-Src, VEGFR2, c-Fms and with IC50s of 0.30, 2.2, and 14.0 μM, respectively.

References:

  1. Perry S Brignola, et al. Comparison of the biochemical and kinetic properties of the type 1 receptor tyrosine kinase intracellular domains. Demonstration of differential sensitivity to kinase inhibitors. J Biol Chem. 2002 Jan 11;277(2):1576-85.

Products are for research use only. Not for human use.

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