Description
6-Benzoylheteratisine is a naturally occurring antagonist of the Na+ channel activator aconitine.
Product information
CAS Number: 99759-48-5
Molecular Weight: 495.61
Formula: C29H37NO6
Chemical Name: (1R,2R,3S,6S,9S,10R,11R,14R,17S,18R,19S)-12-ethyl-2,3,10,11,18-pentahydrogenio-9-hydroxy-17-methoxy-14-methyl-4-oxo-5-oxa-12-azahexacyclo[8.7.2.1²,⁶.0¹,¹¹.0³,⁹.0¹⁴,¹⁸]icosan-19-yl benzoate
Smiles: C[C@@]12CC[C@H](OC)[C@]34[C@@H]1[C@H](OC(=O)C1C=CC=CC=1)[C@@H]([C@H]3N(C2)CC)[C@@]1(O)CC[C@H]2C[C@@H]4[C@@H]1C(=O)O2
InChiKey: XVVZJDDPRFFKTQ-UHDSVDSASA-N
InChi: InChI=1S/C29H37NO6/c1-4-30-15-27(2)12-11-19(34-3)29-18-14-17-10-13-28(33,20(18)26(32)35-17)21(24(29)30)22(23(27)29)36-25(31)16-8-6-5-7-9-16/h5-9,17-24,33H,4,10-15H2,1-3H3/t17-,18+,19-,20+,21-,22+,23+,24+,27-,28+,29+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
6-Benzoylheteratisine (3 μM) decreases the amplitude of the presynaptic fiber spike at all stimulus intensities tested and shiftes the curve to the right. 6-benzoylheteratisine is capable of inhibiting stimulus-triggered epileptiform activity recorded in CA1 stratum pyramidale.
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