Sodium aescinate

Sodium aescinate is a triterpene saponin derived from Aesculus hippocastanum seeds, with anti-inflammatory and antioxidant activities. Sodium aescinate inhibits hepatocellular carcinoma growth by targeting CARMA3/NF-κB pathway.

Product information

CAS Number: 20977-05-3

Molecular Weight: 1123.21

Formula: C54H83NaO23

Chemical Name: sodium (2S,3S,4S,5R,6R)-6-{[(1R,3S,4R,7R,8R,9S,12R,13R,17S,20S,21R,22S)-22-({[3-(acetyloxy)-2-methylbutanoyl]oxy}methyl)-7,13,17-trihydrogenio-21-hydroxy-8-(hydroxymethyl)-3,4,8,12,19,19-hexamethyl-23-oxahexacyclo[18.2.1.0³,¹⁶.0⁴,¹³.0⁷,¹².0¹⁷,²²]tricos-15-en-9-yl]oxy}-4-hydroxy-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-{[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy}oxane-2-carboxylate

Smiles: CC1(C)C[C@H]2C3=CC[C@H]4[C@@](C)(CC[C@H]5[C@](C)(CO)[C@H](CC[C@@]54C)O[C@@H]4O[C@@H]([C@@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@H](O)[C@H]4O[C@@H]4OC[C@@H](O)[C@H](O)[C@H]4O)C(=O)O[Na])[C@]3(C)C[C@H]3O[C@@H]1[C@H](O)[C@]32COC(=O)C(C)C(C)OC(C)=O

InChiKey: OJTQULAMLNBGOY-MPAATTOTSA-M

InChi: InChI=1S/C54H84O23.Na/c1-22(23(2)71-24(3)57)45(68)70-21-54-26-16-49(4,5)43(42(54)65)73-32(54)17-53(9)25(26)10-11-30-50(6)14-13-31(51(7,20-56)29(50)12-15-52(30,53)8)74-48-40(76-46-36(62)33(59)27(58)19-69-46)38(64)39(41(77-48)44(66)67)75-47-37(63)35(61)34(60)28(18-55)72-47;/h10,22-23,26-43,46-48,55-56,58-65H,11-21H2,1-9H3,(H,66,67);/q;+1/p-1/t22?,23?,26-,27+,28+,29+,30+,31-,32+,33-,34+,35-,36+,37+,38-,39-,40+,41-,42-,43+,46-,47-,48+,50-,51-,52+,53+,54-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Sodium aescinate can block signals transiting to downstream molecules AKT, ERK, inhibit the proliferation of breast cancer cell MCF-7 cell apoptosis and induced cell apoptosis by suppressing the activation of SRC.

In Vivo:

Sodium aescinate may effectively controls and improves wound healing in diabetic rats via its anti-inflammatory and antioxidant activities. Sodium aescinate treatment can alleviate the symptom of polycystic ovary syndrome (PCOS) in rat model through regulating the PI3K/Akt/GSK3-β pathway.

Products are for research use only. Not for human use.