Description
DS-1001b is an oral selective inhibitor of mutant IDH1 R132X with potential antineoplastic activity and is designed to penetrate the blood-brain barrier.
Product information
CAS Number: 1898207-64-1
Molecular Weight: 608.92
Formula: C29H29Cl3FN3O4
Chemical Name: 2-methylpropan-2-amine; 3-{1-[5-(2-fluoropropan-2-yl)-3-(2,4,6-trichlorophenyl)-1,2-oxazole-4-carbonyl]-3-methyl-1H-indol-4-yl}prop-2-enoic acid
Smiles: CC(C)(C)N.CC1=CN(C2=CC=CC(C=CC(O)=O)=C12)C(=O)C1C(=NOC=1C(C)(C)F)C1C(Cl)=CC(Cl)=CC=1Cl
InChiKey: UPPAAWQBZQBNIE-USRGLUTNSA-N
InChi: InChI=1S/C25H18Cl3FN2O4.C4H11N/c1-12-11-31(17-6-4-5-13(19(12)17)7-8-18(32)33)24(34)21-22(30-35-23(21)25(2,3)29)20-15(27)9-14(26)10-16(20)28;1-4(2,3)5/h4-11H,1-3H3,(H,32,33);5H2,1-3H3/b8-7+;
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Solubility (25°C). 14 mg/mL(22.99 mM). Insoluble.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
DS-1001b impairs the proliferation of IDH1 mutant chondrosarcoma cell lines and decreases 2-HG levels.
In Vivo:
Continuous administration of DS-1001b impairs tumor growth in xenograft mice.
Products are for research use only. Not for human use.
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