Kobusin


Catalog No. Size PriceQuantity
M15062-2 Contact sales@xcessbio.com for quotation $100

Description

Kobusin is a bisepoxylignan isolated from the Pnonobio biondii Pamp. Kobusin is an activator of CFTR and CaCCgie chloride channels and a inhibitor of ANO1/CaCC (calcium-activated chloride channel) channel.

Product information

CAS Number: 36150-23-9

Molecular Weight: 370.40

Formula: C21H22O6

Chemical Name: 5-[(1S,3aR,4S,6aR)-4-(3,4-dimethoxyphenyl)-3a,6a-dihydrogenio-hexahydrofuro[3,4-c]furan-1-yl]-2H-1,3-benzodioxole

Smiles: COC1=CC(=CC=C1OC)[C@H]1OC[C@@H]2[C@H](OC[C@@H]21)C1C=C2OCOC2=CC=1

InChiKey: AWOGQCSIVCQXBT-VUEDXXQZSA-N

InChi: InChI=1S/C21H22O6/c1-22-16-5-3-12(7-18(16)23-2)20-14-9-25-21(15(14)10-24-20)13-4-6-17-19(8-13)27-11-26-17/h3-8,14-15,20-21H,9-11H2,1-2H3/t14-,15-,20+,21+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Kobusin could activate the function of CFTR and CaCCgie (CaCC expressed in gastrointestinal epithelial cells) chloride channels. Notably, Kobusin could inhibit the activities ANO1/CaCC chloride channel in ANO1/CaCC-expressing FRT cells.

In Vivo:

In charcoal transit study, Kobusin mildly reduced gastrointestinal motility in mice.

Products are for research use only. Not for human use.

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