Description
Empesertib (BAY 1161909) is a potent Mps1 inhibitor, with an IC50 of < 1 nM.
Product information
CAS Number: 1443763-60-7
Molecular Weight: 559.61
Formula: C29H26FN5O4S
Chemical Name: (2R)-2-(4-fluorophenyl)-N-(4-{2-[(4-methanesulfonyl-2-methoxyphenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl}phenyl)propanamide
Smiles: COC1=CC(=CC=C1NC1N=C2C=CC(=CN2N=1)C1C=CC(=CC=1)NC(=O)[C@H](C)C1C=CC(F)=CC=1)S(C)(=O)=O
InChiKey: NRJKIOCCERLIDG-GOSISDBHSA-N
InChi: InChI=1S/C29H26FN5O4S/c1-18(19-4-9-22(30)10-5-19)28(36)31-23-11-6-20(7-12-23)21-8-15-27-33-29(34-35(27)17-21)32-25-14-13-24(40(3,37)38)16-26(25)39-2/h4-18H,1-3H3,(H,31,36)(H,32,34)/t18-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 35 mg/mL (62.54 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
BAY 1161909 is a potent Mps1 inhibitor, with an IC50 of < 1 nM. BAY 1161909 also shows anti-tumor effect, suppressing the proliferation of Hela cells, with an IC50 of < 400 nM.
Products are for research use only. Not for human use.
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