Description
JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.
Product information
CAS Number: 1363281-27-9
Molecular Weight: 352.36
Formula: C20H17FN2O3
Chemical Name: 5-(4-fluorobenzoyl)-2-(phenoxymethyl)-4H,5H,6H,7H-[1,3]oxazolo[5,4-c]pyridine
Smiles: O=C(C1C=CC(F)=CC=1)N1CC2OC(COC3C=CC=CC=3)=NC=2CC1
InChiKey: QUZLMKNNIUSREV-UHFFFAOYSA-N
InChi: InChI=1S/C20H17FN2O3/c21-15-8-6-14(7-9-15)20(24)23-11-10-17-18(12-23)26-19(22-17)13-25-16-4-2-1-3-5-16/h1-9H,10-13H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : ≥ 125 mg/mL (354.75 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR−/− mice. The administration of JNJ-46778212 to SR−/− mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory.
Products are for research use only. Not for human use.
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