JNJ-46778212


Catalog No. Size PriceQuantity
M15411-2 Contact sales@xcessbio.com for quotation $100

Description

JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.

Product information

CAS Number: 1363281-27-9

Molecular Weight: 352.36

Formula: C20H17FN2O3

Chemical Name: 5-(4-fluorobenzoyl)-2-(phenoxymethyl)-4H,5H,6H,7H-[1,3]oxazolo[5,4-c]pyridine

Smiles: O=C(C1C=CC(F)=CC=1)N1CC2OC(COC3C=CC=CC=3)=NC=2CC1

InChiKey: QUZLMKNNIUSREV-UHFFFAOYSA-N

InChi: InChI=1S/C20H17FN2O3/c21-15-8-6-14(7-9-15)20(24)23-11-10-17-18(12-23)26-19(22-17)13-25-16-4-2-1-3-5-16/h1-9H,10-13H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 125 mg/mL (354.75 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR−/− mice. The administration of JNJ-46778212 to SR−/− mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory.

Products are for research use only. Not for human use.

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