AGN-201904Z

AGN-201904Z or AGN 201904-Z is a new, slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time. AGN 201904-Z produced a significantly greater and more prolonged acid suppression than esomeprazole, and nocturnal acid suppression was more prolonged over all 5 days. AGN 201904-Z should provide true once-a-day treatment and better clinical efficacy than current PPIs.

Product information

CAS Number: 651728-41-5

Molecular Weight: 581.59

Formula: C25H24N3NaO8S2

Chemical Name: sodium 2-(4-(5-methoxy-2-((4-methoxy-3, 5-dimethylpyridin-2-yl)methylsulfinyl)-1H-benzo[d]imidazol-1-ylsulfonyl)phenoxy)acetate

Smiles: [Na+].CC1=CN=C(CS(=O)C2=NC3=CC(=CC=C3N2S(=O)(=O)C2C=CC(=CC=2)OCC([O-])=O)OC)C(C)=C1OC

InChiKey: VHTOWLOOYYGTNQ-UHFFFAOYSA-M

InChi: InChI=1S/C25H25N3O8S2.Na/c1-15-12-26-21(16(2)24(15)35-4)14-37(31)25-27-20-11-18(34-3)7-10-22(20)28(25)38(32,33)19-8-5-17(6-9-19)36-13-23(29)30;/h5-12H,13-14H2,1-4H3,(H,29,30);/q;+1/p-1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Sachs G, Shin JM, Hunt R. Novel approaches to inhibition of gastric acid secretion. Curr Gastroenterol Rep. 2010 Dec;12(6):437-47.
2. Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Sep;29(7):467-509.
3. Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 May;29(4):303-11.

Products are for research use only. Not for human use.