Icariside E5


Catalog No. Size PriceQuantity
M15603-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Icariside E5 is a lignan glycoside isolated from the Albiziae Cortex. Icariside E5 promotes the proliferation of HUVECs without cytotoxicity. Icariside E5 has antioxidant properties.

Product information

CAS Number: 126176-79-2

Molecular Weight: 522.54

Formula: C26H34O11

Chemical Name: (2S, 3R, 4S, 5S, 6R)-2-(2-((R)-1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propan-2-yl)-4-((E)-3-hydroxyprop-1-en-1-yl)-6-methoxyphenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3, 4, 5-triol

Smiles: COC1=CC(C[C@@H](CO)C2C=C(C=C(OC)C=2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)/C=C/CO)=CC=C1O

InChiKey: UFFRBCKYXMEITK-RUBGFCLFSA-N

InChi: InChI=1S/C26H34O11/c1-34-19-10-15(5-6-18(19)30)8-16(12-28)17-9-14(4-3-7-27)11-20(35-2)25(17)37-26-24(33)23(32)22(31)21(13-29)36-26/h3-6,9-11,16,21-24,26-33H,7-8,12-13H2,1-2H3/b4-3+/t16-,21+,22+,23-,24+,26-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Icariside E5 (5, 10, 20, 40 µM; for 48 h) slightly promotes the proliferation of human umbilical vein endothelial cells (HUVECs). Icariside E5 does not have the pharmacological effect of scavenging ROS. Icariside E neither induces an increase in the intracellular levels of reactive oxygen species nor affects the mitochondria permeability transition, and it does not signal through the vanilloid receptor type 1. It protects Jurkat cells from apoptosis induced by the oxidative stress mediated by serum withdrawal.

Products are for research use only. Not for human use.

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