Description
Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer.
Product information
CAS Number: 119152-50-0
Molecular Weight: 446.36
Formula: C21H18O11
Chemical Name: (2S, 3S, 4S, 5R, 6S)-6-[(5, 8-dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]-3, 4, 5-trihydroxyoxane-2-carboxylic acid
Smiles: OC(=O)[C@H]1O[C@@H](OC2=CC(O)=C3C(OC(=CC3=O)C3C=CC=CC=3)=C2O)[C@H](O)[C@@H](O)[C@@H]1O
InChiKey: MOFOLNOWFPVLGZ-BHWDSYMASA-N
InChi: InChI=1S/C21H18O11/c22-9-6-11(8-4-2-1-3-5-8)30-18-13(9)10(23)7-12(14(18)24)31-21-17(27)15(25)16(26)19(32-21)20(28)29/h1-7,15-17,19,21,23-27H,(H,28,29)/t15-,16-,17+,19-,21+/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Glychionide A (3.12-100 μM) significantly inhibits the proliferation of the PANC-1 pancreatic cancer cells, with an IC50 of 14 μM. Glychionide A (7-28 μM) induces both autophagy and apoptosis in pancreatic cancer cells. Glychionide A (7-28 μM) causes G2/M arrest of PANC-1 pancreatic cancer cells. Glychionide A (7-28 μM) causes generation of ROS in PANC-1 cells.
Products are for research use only. Not for human use.
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