Description
Emodin-6-O-β-D-glucoside (Glucoemodin) is an active compound from Reynoutria japonica. Emodin-6-O-β-D-glucoside shows potent anti-inflammatory and barrier protective effects. Emodin-6-O-β-D-glucoside can be used for the research of diabetic complications and atherosclerosis.
Product information
CAS Number: 34298-85-6
Molecular Weight: 432.38
Formula: C21H20O10
Chemical Name: 1,8-dihydroxy-3-methyl-6-{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-9,10-dihydroanthracene-9,10-dione
Smiles: CC1=CC(O)=C2C(=C1)C(=O)C1=CC(=CC(O)=C1C2=O)O[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O
InChiKey: UBVJENDWBOVRBS-FHTSYUTFSA-N
InChi: InChI=1S/C21H20O10/c1-7-2-9-14(11(23)3-7)18(27)15-10(16(9)25)4-8(5-12(15)24)30-21-20(29)19(28)17(26)13(6-22)31-21/h2-5,13,17,19-24,26,28-29H,6H2,1H3/t13-,17+,19+,20-,21+/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Emodin-6-O-β-D-glucoside (0~20 μM; 24 hours; HUVECs) does not affect cell viability. Emodin-6-O-β-D-glucoside (0~10 μM; 6 hours; HUVECs) results in a dose dependent decrease in high glucose-mediated membrane disruption, inhibits high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin and results in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA. Emodin-6-O-β-D-glucoside (10 μM; 6 hours; HUVECs) results in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs. Emodin-6-O-β-D-glucoside pretreatment significantly inhibits high-glucose-induced ROS formation and p65 NF-κB expression levels increase.
In Vivo:
Emodin-6-O-β-D-glucoside (0~9 mg/mouse; i.v.) markly inhibits peritoneal leakage of dye induced by high glucose.
Products are for research use only. Not for human use.
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