Description
Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM). Aβ42-IN-1 potently reduced Aβ42 levels with an IC50 value of 0.091 µM without CYP3A4 inhibition. Aβ42-IN-1 shows a sustained pharmacokinetic profile.
Product information
Molecular Weight: 499.00
Formula: C29H27ClN4O2
Chemical Name: 5-(8-([1, 1'-biphenyl]-4-ylmethoxy)-2-methylimidazo[1, 2-a]pyridin-3-yl)-N-ethylpicolinamide hydrochloride
Smiles: Cl.CC1N=C2C(=CC=CN2C=1C1=CN=C(C=C1)C(=O)NCC)OCC1=CC=C(C=C1)C1=CC=CC=C1
InChiKey: PXGSUAWOGFXNSZ-UHFFFAOYSA-N
InChi: InChI=1S/C29H26N4O2.ClH/c1-3-30-29(34)25-16-15-24(18-31-25)27-20(2)32-28-26(10-7-17-33(27)28)35-19-21-11-13-23(14-12-21)22-8-5-4-6-9-22;/h4-18H,3,19H2,1-2H3,(H,30,34);1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Aβ42-IN-1 (orally adminstation; 30 mg/kg)shows a good pharmacokinetic profile in mice, significantly reduces Aβ42 levels in the brain and plasma, by 36% and 66%, respectively. while the brain/plasma ratio of 1v is slightly lower than that of 1a.
Products are for research use only. Not for human use.
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