Description
AV-153 free base, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 free base interacts with thymine and cytosine and has an influence on poly(ADP)ribosylation. AV-153 free base has anti-cancer activity.
Product information
CAS Number: 19350-66-4
Molecular Weight: 297.30
Formula: C14H19NO6
Chemical Name: 3,5-bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylic acid
Smiles: CC1NC(C)=C(C(C(O)=O)C=1C(=O)OCC)C(=O)OCC
InChiKey: USGQSNVLGQWBEC-UHFFFAOYSA-N
InChi: InChI=1S/C14H19NO6/c1-5-20-13(18)9-7(3)15-8(4)10(11(9)12(16)17)14(19)21-6-2/h11,15H,5-6H2,1-4H3,(H,16,17)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 250 mg/mL (840.90 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
AV-153 free base causes IC50s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively. AV-153 free base (1 nM to 10 μM; 3 hours) reduces the level of spontaneously arising DNA single-strand breaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 13–67%.
Products are for research use only. Not for human use.
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