Description
A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively.
Product information
CAS Number: 280749-17-9
Molecular Weight: 453.55
Formula: C24H27N3O4S
Chemical Name: (2E)-1-(4-acetylpiperazin-1-yl)-3-(3-nitro-4-{[2-(propan-2-yl)phenyl]sulfanyl}phenyl)prop-2-en-1-one
Smiles: CC(=O)N1CCN(CC1)C(=O)/C=C/C1=CC(=C(C=C1)SC1=CC=CC=C1C(C)C)[N+]([O-])=O
InChiKey: HTGGAYLWTDOFDK-PKNBQFBNSA-N
InChi: InChI=1S/C24H27N3O4S/c1-17(2)20-6-4-5-7-22(20)32-23-10-8-19(16-21(23)27(30)31)9-11-24(29)26-14-12-25(13-15-26)18(3)28/h4-11,16-17H,12-15H2,1-3H3/b11-9+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
A-286982 binds to the I domain allosteric site (IDAS). The allosteric ICAM inhibition such as this would be expected to exhibit the unsurmountable competition we have observed for A-286982 as a result of the passage of this allostery through the A-286982 binding site in its transmission from the β subunit I-like domain to the α subunit ICAM binding site.
Products are for research use only. Not for human use.
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