BCAT-IN-2


Catalog No. Size PriceQuantity
M16815-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6). BCAT-IN-2 can be used for the research of obesity and dislipidema.

Product information

CAS Number: 1800024-45-6

Molecular Weight: 377.78

Formula: C17H14ClF2N5O

Chemical Name: 2-{[(4-chloro-2,6-difluorophenyl)methyl]amino}-7-oxo-5-propyl-1H,7H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Smiles: CCCC1=CC(=O)N2NC(NCC3=C(F)C=C(Cl)C=C3F)=C(C#N)C2=N1

InChiKey: URTVEMYYYIZBNE-UHFFFAOYSA-N

InChi: InChI=1S/C17H14ClF2N5O/c1-2-3-10-6-15(26)25-17(23-10)11(7-21)16(24-25)22-8-12-13(19)4-9(18)5-14(12)20/h4-6,22,24H,2-3,8H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

BCAT-IN-2 (compound 61) inhibits BCATm in differentiated primary human adipocyte, with pIC50 of 6.5.

In Vivo:

BCAT-IN-2 (compound 61) (10-100 mg/kg; p.o.) increases the level of leucine from 473 μM to 1.2 mM at the dose of 100 mg/kg in mice. BCAT-IN-2 (5 mg/kg for p.o. and 1 mg/kg for i.v.) exhibits a high bioavailability (F=100%), long half-life (t1/2=9.2 h) and low clearance (Cl=0.3 mL/min/kg) in mice.

Products are for research use only. Not for human use.

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