Falcarindiol


Catalog No. Size PriceQuantity
M16828-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties.

Product information

CAS Number: 55297-87-5

Molecular Weight: 260.37

Formula: C17H24O2

Chemical Name: (3R, 8S, 9Z)-heptadeca-1, 9-dien-4, 6-diyne-3, 8-diol

Smiles: CCCCCCC/C=C\[C@H](O)C#CC#C[C@H](O)C=C

InChiKey: QWCNQXNAFCBLLV-YWALDVPYSA-N

InChi: InChI=1S/C17H24O2/c1-3-5-6-7-8-9-10-14-17(19)15-12-11-13-16(18)4-2/h4,10,14,16-19H,2-3,5-9H2,1H3/b14-10-/t16-,17+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Falcarindiol (3, 6, 12, 24 µM; for 24 hours) significantly decreases cell viability of MDA-MB-231 and MDA-MB-468 cells. Cell viability of MCF-10A cells is unchanged until the dose of Falcarindiol reaches to 24 uM. Falcarindiol preferentially induces cell death in breast cancer cells. Falcarindiol (6 uM; for 2 hours) induces autophagy and causes significant level of LC3-I converted to LC3-II in MDA-MB-231, MDA-MB-468 and SKBR3 cells. Falcarindiol (6 uM; for 2, 4, 8, 24 hours) increases the level of GRP78 in MDA-MB-231 cells in dose- and time-dependent manner. Falcarindiol (1-20 µM) has no effect on hMSCs and HT-29 cell viability. Falcarindiol with only concentrations above 50 µM exhibits a toxic effect on the cells. Falcarindiol (5 µM; 10 min, 1 h and 24 h) causes a significant upregulation on PPARγ2 expression at 24 h.

In Vivo:

Falcarindiol (7 µg/g; diet) increases ABCA1 expression in neoplastic tissue in five weeks old male rats.

Products are for research use only. Not for human use.

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