Description
Posizolid (AZD2563), an oxazolidinone antibiotic, is developed by AstraZeneca for the study of bacterial infections. Posizolid shows very good anti-mycobacterial activity.
Product information
CAS Number: 252260-02-9
Molecular Weight: 465.40
Formula: C21H21F2N3O7
Chemical Name: (5R)-3-[4-[1-[(2S)-2, 3-dihydroxypropanoyl]-3, 6-dihydro-2H-pyridin-4-yl]-3, 5-difluorophenyl]-5-(1, 2-oxazol-3-yloxymethyl)-1, 3-oxazolidin-2-one
Smiles: O[C@@H](CO)C(=O)N1CC=C(CC1)C1C(F)=CC(=CC=1F)N1C[C@H](COC2C=CON=2)OC1=O
InChiKey: HBUJYEUPIIJJOS-PBHICJAKSA-N
InChi: InChI=1S/C21H21F2N3O7/c22-15-7-13(26-9-14(33-21(26)30)11-31-18-3-6-32-24-18)8-16(23)19(15)12-1-4-25(5-2-12)20(29)17(28)10-27/h1,3,6-8,14,17,27-28H,2,4-5,9-11H2/t14-,17+/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Posizolid is determined the activity of against 250 highly resistant pneumococci and 267 drug-susceptible isolates. Posizolid MICs for 50 and 90% of the strains tested are 1 and 2 μg/ml and 0.5 and 1 μg/ml, respectively, for the two isolate groups.
In Vivo:
AZD5847 DSP (AZD2563 is prodrug) could not be detected in plasma 5 min after oral administration, suggesting rapid conversion of the prodrug to the parent molecule. In PK analysis, AZD5847(5 mg/kg) shows a low clearance (4.7 ml/min/kg) and volume of distribution (0.5 liter/kg) in mice, the half-life is 1.3 h.
Products are for research use only. Not for human use.
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