2-Pyrrolidinone


Catalog No. Size PriceQuantity
M16847-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

2-Pyrrolidinone is an active compound present in Brassica oleracea var. capitata and displays anticancer property.

Product information

CAS Number: 616-45-5

Molecular Weight: 85.10

Formula: C4H7NO

Chemical Name: pyrrolidin-2-one

Smiles: O=C1CCCN1

InChiKey: HNJBEVLQSNELDL-UHFFFAOYSA-N

InChi: InChI=1S/C4H7NO/c6-4-2-1-3-5-4/h1-3H2,(H,5,6)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Radical scavenging activity increases with increasing the amount of 2-Pyrrolidinone. The cytotoxicity of 2-Pyrrolidinone is found to be dose and time dependent, and the effect is observed microscopically in all of the selected cancer cell lines. It is observed that 2-Pyrrolidinone has cytotoxic concentrations of 2.5 mg/mL for HeLa, 3 mg/mL for PC-3 cells at 24 h and 1.5 mg/mL for HeLa and 2 mg/mL for PC-3 cells at 48 h, respectively. The cell viability decreases with increasing concentrations of purified 2-Pyrrolidinone. After treatment with 2-Pyrrolidinone their IC50 concentrations (1.5 mg/mL and 2 mg/mL for HeLa and PC-3 cells, respectively) for a period of 24 h, morphological changes in the cells are observed. It is demonstrated that 2-Pyrrolidinone induces apoptosis in HeLa and PC-3 cells via G0/G1phase of cell cycle arrest.

Products are for research use only. Not for human use.

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