SJ6986


Catalog No. Size PriceQuantity
M16945-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SJ6986 is a potent, selective and orally active GSPT1/2 degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1.

Product information

Molecular Weight: 497.40

Formula: C20H14F3N3O7S

Chemical Name: N-[2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxoisoindol-5-yl]-2-(trifluoromethoxy)benzenesulfonamide

Smiles: O=C1CCC(C(=O)N1)N1C(=O)C2=CC=C(C=C2C1=O)NS(=O)(=O)C1=CC=CC=C1OC(F)(F)F

InChiKey: RKAFYSIKAVFVPS-UHFFFAOYSA-N

InChi: InChI=1S/C20H14F3N3O7S/c21-20(22,23)33-14-3-1-2-4-15(14)34(31,32)25-10-5-6-11-12(9-10)19(30)26(18(11)29)13-7-8-16(27)24-17(13)28/h1-6,9,13,25H,7-8H2,(H,24,27,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SJ6986 exhibits EC50 values of 1.5 nM, 0.4 nM, 726 nM, 336 nM and 3583 nM in MV4-11, MHH-CALL-4, MB002, MB004 and HD-MB03 cell lines, respectively.

In Vivo:

SJ6986 exhibits t1/2 of 3.44 h by iv injection of 3 mg/kg and tmax of 0.25 h by oral administration (%F = 84) of 10 mg/kg in CD1 mice.

Products are for research use only. Not for human use.

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