Diaplasinin


Catalog No. Size PriceQuantity
M16976-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nm. Antithrombotic efficacy.

Product information

CAS Number: 481631-45-2

Molecular Weight: 501.62

Formula: C32H31N5O

Chemical Name: 1-benzyl-3-pentyl-2-{6-[(2H-1,2,3,4-tetrazol-5-yl)methoxy]naphthalen-2-yl}-1H-indole

Smiles: CCCCCC1=C(C2=CC3=CC=C(C=C3C=C2)OCC2=NNN=N2)N(CC2C=CC=CC=2)C2=CC=CC=C21

InChiKey: BDPXZFKVHDEPIQ-UHFFFAOYSA-N

InChi: InChI=1S/C32H31N5O/c1-2-3-5-13-29-28-12-8-9-14-30(28)37(21-23-10-6-4-7-11-23)32(29)26-16-15-25-20-27(18-17-24(25)19-26)38-22-31-33-35-36-34-31/h4,6-12,14-20H,2-3,5,13,21-22H2,1H3,(H,33,34,35,36)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PAI-749 is a potent and selective synthetic antagonist of plasminogen activator inhibitor 1 (PAI-1) that preserved tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) activities in the presence of PAI-1 (IC50 values, 157 and 87 nM, respectively). PAI-749 quenches the fluorescence (Fl) of fluorophore-tagged PAI-1 (PAI-NBD119) with the apparent Kd of 254 nM) and the IC50 of 140 nM.

Products are for research use only. Not for human use.

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