Description
CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research.
Product information
CAS Number: 1391385-57-1
Molecular Weight: 334.80
Formula: C17H19ClN2O3
Chemical Name: 1-(3-chlorophenethyl)-3-cyclopentylpyrimidine-2, 4, 6(1H, 3H, 5H)-trione
Smiles: O=C1CC(=O)N(CCC2C=CC=C(Cl)C=2)C(=O)N1C1CCCC1
InChiKey: AJKSBVCOTKODMF-UHFFFAOYSA-N
InChi: InChI=1S/C17H19ClN2O3/c18-13-5-3-4-12(10-13)8-9-19-15(21)11-16(22)20(17(19)23)14-6-1-2-7-14/h3-5,10,14H,1-2,6-9,11H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for CaV1.3 and CaV1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.