CaV1.3 antagonist-1


Catalog No. Size PriceQuantity
M17026-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research.

Product information

CAS Number: 1391385-57-1

Molecular Weight: 334.80

Formula: C17H19ClN2O3

Chemical Name: 1-(3-chlorophenethyl)-3-cyclopentylpyrimidine-2, 4, 6(1H, 3H, 5H)-trione

Smiles: O=C1CC(=O)N(CCC2C=CC=C(Cl)C=2)C(=O)N1C1CCCC1

InChiKey: AJKSBVCOTKODMF-UHFFFAOYSA-N

InChi: InChI=1S/C17H19ClN2O3/c18-13-5-3-4-12(10-13)8-9-19-15(21)11-16(22)20(17(19)23)14-6-1-2-7-14/h3-5,10,14H,1-2,6-9,11H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for CaV1.3 and CaV1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay.

Products are for research use only. Not for human use.

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