Description
Protein deglycase DJ-1 against-1, a DJ-1-binding compound, dependently targets DJ1. Protein deglycase DJ-1 against-1 penetrates through the blood brain barrier (BBB). Protein deglycase DJ-1 against-1 is used as a neuroprotective agent and has the potential for Parkinson's disease research.
Product information
CAS Number: 724737-74-0
Molecular Weight: 417.46
Formula: C24H23N3O4
Chemical Name: 3, 4, 5-trimethoxy-N-(4-{8-methylimidazo[1, 2-a]pyridin-2-yl}phenyl)benzamide
Smiles: CC1=CC=CN2C=C(N=C21)C1C=CC(=CC=1)NC(=O)C1=CC(OC)=C(OC)C(=C1)OC
InChiKey: DRVIKYTZILDXIS-UHFFFAOYSA-N
InChi: InChI=1S/C24H23N3O4/c1-15-6-5-11-27-14-19(26-23(15)27)16-7-9-18(10-8-16)25-24(28)17-12-20(29-2)22(31-4)21(13-17)30-3/h5-14H,1-4H3,(H,25,28)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 25 mg/mL (59.89 mM; ultrasonic and adjust pH to 7 with NaOH).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
Protein deglycase DJ-1 against-1 (compound-23; 1 mg/kg; IP; pretreatment one hour; daily; for 4 days) significantly restores MPTP induced locomotion, dopaminergic neuronal cell death and dopamine content in DJ-1(+/+) mice but not in DJ-1(-/-) mice.
Products are for research use only. Not for human use.
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