Description
L748337 is a potent β3-adrenergic receptor antagonist and displays selectivity over β1 and β2 receptors. The Ki values of L748337 for β3-, β2- and β1-adrenoceptors are 4.0 nM, 204 nM and 390 nM, respectively. L748337 couples predominantly to Gi to activate MAPK signaling and increases phosphorylation of Erk1/2 with pEC50 value of 11.6. L748337 can be used for the research of cancer, nonalcoholic fatty liver disease (NAFLD), and cardiovascular related diseases.
Product information
CAS Number: 244192-94-7
Molecular Weight: 497.61
Formula: C26H31N3O5S
Chemical Name: N-({3-[(2S)-3-{[2-(4-benzenesulfonamidophenyl)ethyl]amino}-2-hydroxypropoxy]phenyl}methyl)acetamide
Smiles: CC(=O)NCC1C=C(C=CC=1)OC[C@@H](O)CNCCC1C=CC(=CC=1)NS(=O)(=O)C1C=CC=CC=1
InChiKey: AWIONHVPTYTSHZ-DEOSSOPVSA-N
InChi: InChI=1S/C26H31N3O5S/c1-20(30)28-17-22-6-5-7-25(16-22)34-19-24(31)18-27-15-14-21-10-12-23(13-11-21)29-35(32,33)26-8-3-2-4-9-26/h2-13,16,24,27,29,31H,14-15,17-19H2,1H3,(H,28,30)/t24-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 25 mg/mL (50.24 mM; Need ultrasonic and warming).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
L748337 (1 μM) inhibits iNOS expression in B16F10 cells.
In Vivo:
L-748337 (intraperitoneal injection; 5 mg/kg; beginning 10 days until D18) decreases the growth of melanoma induced by B16F10 cell inoculation and decreases tumor vasculature in mice.
Products are for research use only. Not for human use.
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