Description
MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration.
Product information
CAS Number: 1382799-40-7
Molecular Weight: 268.28
Formula: C9H14F2N2O3S
Chemical Name: (3aR,5S,6S,7R,7aR)-5-(difluoromethyl)-2-(ethylimino)-hexahydro-1H-pyrano[3,2-d][1,3]thiazole-6,7-diol
Smiles: CCN=C1N[C@H]2[C@H](O[C@H](C(F)F)[C@@H](O)[C@@H]2O)S1
InChiKey: UDQTXCHQKHIQMH-KYGLGHNPSA-N
InChi: InChI=1S/C9H14F2N2O3S/c1-2-12-9-13-3-4(14)5(15)6(7(10)11)16-8(3)17-9/h3-8,14-15H,2H2,1H3,(H,12,13)/t3-,4-,5+,6+,8-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
MK-8719 has excellent intrinsic potency and selectivity, improved Papp, high CNS exposure, good pharmacokinetics, favorable metabolic stability, and robust pharmacodynamic response.
Products are for research use only. Not for human use.
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