CCR4 antagonist 2


Catalog No. Size PriceQuantity
M17485-C Contact sales@xcessbio.com for quotation $100

Description

CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.

Product information

CAS Number: 2206788-99-8

Molecular Weight: 511.45

Formula: C26H28Cl2N6O

Chemical Name: 1-[(1R)-1-(2, 4-dichlorophenyl)ethyl]-6-[(4S, 5R)-4-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-5-methylcyclohexen-1-yl]pyrazolo[3, 4-b]pyrazine-3-carbonitrile

Smiles: C[C@@H]1CC(=CC[C@@H]1N1CCC[C@H]1CO)C1=CN=C2C(=N1)N(N=C2C#N)[C@H](C)C1=CC=C(Cl)C=C1Cl

InChiKey: KQZLRWGGWXJPOS-NLFPWZOASA-N

InChi: InChI=1S/C26H28Cl2N6O/c1-15-10-17(5-8-24(15)33-9-3-4-19(33)14-35)23-13-30-25-22(12-29)32-34(26(25)31-23)16(2)20-7-6-18(27)11-21(20)28/h5-7,11,13,15-16,19,24,35H,3-4,8-10,14H2,1-2H3/t15-,16-,19+,24+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.

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