Lenalidomide-C9-aldehyde


Catalog No. Size PriceQuantity
M17543-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Lenalidomide-C9-aldehyde is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a linker. Lenalidomide-C9-aldehyde can be used in the synthesis of a series of PROTACs, such as INY-03-041 (HY-133120). INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively.

Product information

Molecular Weight: 398.50

Formula: C23H30N2O4

Chemical Name: 10-[2-(2, 6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]decanal

Smiles: O=CCCCCCCCCCC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O

InChiKey: SRMIWVGSHCPOQU-UHFFFAOYSA-N

InChi: InChI=1S/C23H30N2O4/c26-15-8-6-4-2-1-3-5-7-10-17-11-9-12-18-19(17)16-25(23(18)29)20-13-14-21(27)24-22(20)28/h9,11-12,15,20H,1-8,10,13-14,16H2,(H,24,27,28)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Lenalidomide is a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). INY-03-041 is a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to Lenalidomide by a linker.

Products are for research use only. Not for human use.

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