Description
RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.
Product information
CAS Number: 2488788-52-7
Molecular Weight: 499.91
Formula: C22H25ClF3N5O3
Chemical Name: N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-2-chloro-6-(4-methoxyoxane-4-carbonyl)-5H, 6H, 7H-pyrrolo[3, 4-d]pyrimidin-4-amine
Smiles: COC1(CCOCC1)C(=O)N1CC2=NC(Cl)=NC(N[C@H](C)C3C=C(N)C=C(C=3)C(F)(F)F)=C2C1
InChiKey: HOBOGRTXXDLZIB-GFCCVEGCSA-N
InChi: InChI=1S/C22H25ClF3N5O3/c1-12(13-7-14(22(24,25)26)9-15(27)8-13)28-18-16-10-31(11-17(16)29-20(23)30-18)19(32)21(33-2)3-5-34-6-4-21/h7-9,12H,3-6,10-11,27H2,1-2H3,(H,28,29,30)/t12-/m1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (250.05 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
RMC-0331 has an IC50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro.
In Vivo:
RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models.
Products are for research use only. Not for human use.
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