DAD


Catalog No. Size PriceQuantity
M17624-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

DAD is a type of ion channel blocker that blocks voltage-gated potassium channels. DAD is a third-generation photoswitch that responds to visible light. DAD has the potential for restoring visual function.

Product information

Molecular Weight: 452.64

Formula: C26H40N6O

Chemical Name: (E)-2-(diethylamino)-N-(4-((4-((2-(diethylamino)ethyl)(ethyl)amino)phenyl)diazenyl)phenyl)acetamide

Smiles: CCN(CCN(CC)CC)C1C=CC(=CC=1)/N=N/C1C=CC(=CC=1)NC(=O)CN(CC)CC

InChiKey: WQECYMBPMDXORX-ZQHSETAFSA-N

InChi: InChI=1S/C26H40N6O/c1-6-30(7-2)19-20-32(10-5)25-17-15-24(16-18-25)29-28-23-13-11-22(12-14-23)27-26(33)21-31(8-3)9-4/h11-18H,6-10,19-21H2,1-5H3,(H,27,33)/b29-28+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

DAD is not permanently charged, and the uncharged form enables the photoswitch to rapidly and effectively cross biological barriers and thereby access and photosensitize retinal neurons. DAD selectively photosensitizes retinal neurons upstream of retinal ganglion cells (RGCs). DAD is capable of restoring retinal ganglion cell light responses to blue or white light.

In Vivo:

Intravitreal injection of DAD restores retinal light responses and light-driven behavior to blind mice. DAD acts upstream of retinal ganglion cells, primarily conferring light sensitivity to bipolar cells. DAD is capable of generating ON and OFF visual responses in the blind retina by utilizing intrinsic retinal circuitry.

Products are for research use only. Not for human use.

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