AT-9010 tetrasodium


Catalog No. Size PriceQuantity
M17631-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

AT-9010 tetrasodium, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 tetrasodium can inhibit SARS-CoV-2 replication.

Product information

CAS Number: 1621884-18-1

Molecular Weight: 627.13

Formula: C11H13FN5Na4O13P3

Chemical Name: sodium [({[(2R, 3R, 4R, 5R)-5-(2-amino-6-oxo-6, 9-dihydro-3H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy}(sodiooxy)phosphoryl)oxy]({[bis(sodiooxy)phosphoryl]oxy})phosphinate

Smiles: C[C@@]1(F)[C@H](O)[C@@H](COP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O[Na])O[C@H]1N1C=NC2=C1NC(N)=NC2=O

InChiKey: YSFIWHKJCYGPPP-ZJECJYFYSA-J

InChi: InChI=1S/C11H17FN5O13P3.4Na/c1-11(12)6(18)4(2-27-32(23,24)30-33(25,26)29-31(20,21)22)28-9(11)17-3-14-5-7(17)15-10(13)16-8(5)19;;;;/h3-4,6,9,18H,2H2,1H3,(H,23,24)(H,25,26)(H2,20,21,22)(H3,13,15,16,19);;;;/q;4*+1/p-4/t4-,6-,9-,11-;;;;/m1..../s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Substantial levels of the active triphosphate metabolite AT-9010 are formed in normal human bronchial and nasal epithelial cells incubated with 10 µM AT-511 (698 µM and 236 µM, respectively), with a half-life of at least 38 hours.

Products are for research use only. Not for human use.

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