PSMα3 TFA

PSMα3 TFA is a peptide for manipulating DCs to become tolerogenic for DC vaccination strategies. PSMα3 TFA penetrates and modulates human monocyte-derived DCs by altering the TLR2- or TLR4-induced maturation, inhibiting pro- and anti-inflammatory cytokine production and reducing antigen uptake. PSMα3 TFA is an important toxin released by the most virulent strains of methicillin-resistant Staphylococcus aureus (MRSA).

Product information

Molecular Weight: 2749.15

Formula: C130H193F3N28O32S

Chemical Name: PSMalpha3 TFA

Smiles: C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O.OC(=O)C(F)(F)F

InChiKey: IFHDHRPNQPIYGS-LWVFVFCRSA-N

InChi: InChI=1S/C128H192N28O30S.C2HF3O2/c1-73(2)58-90(110(167)135-70-104(160)139-85(46-28-32-53-129)113(170)149-96(64-81-40-22-15-23-41-81)122(179)146-91(59-74(3)4)111(168)136-71-105(161)140-99(67-102(133)158)124(181)155-101(128(185)186)68-103(134)159)145-118(175)93(61-76(7)8)148-125(182)100(69-107(164)165)154-116(173)88(49-31-35-56-132)143-121(178)95(63-80-38-20-14-21-39-80)153-123(180)97(65-82-42-24-16-25-43-82)150-115(172)87(48-30-34-55-131)142-120(177)94(62-79-36-18-13-19-37-79)152-119(176)92(60-75(5)6)147-114(171)86(47-29-33-54-130)141-109(166)78(11)138-127(184)108(77(9)10)156-126(183)98(66-83-44-26-17-27-45-83)151-117(174)89(50-51-106(162)163)144-112(169)84(137-72-157)52-57-187-12;3-2(4,5)1(6)7/h13-27,36-45,72-78,84-101,108H,28-35,46-71,129-132H2,1-12H3,(H2,133,158)(H2,134,159)(H,135,167)(H,136,168)(H,137,157)(H,138,184)(H,139,160)(H,140,161)(H,141,166)(H,142,177)(H,143,178)(H,144,169)(H,145,175)(H,146,179)(H,147,171)(H,148,182)(H,149,170)(H,150,172)(H,151,174)(H,152,176)(H,153,180)(H,154,173)(H,155,181)(H,156,183)(H,162,163)(H,164,165)(H,185,186);(H,6,7)/t78-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,108-;/m0./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.