CM121


Catalog No. Size PriceQuantity
M17694-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CM121 is an active site-directed reversible ALDH1A2 inhibitor (IC50=0.54 μM;Kd=1.1 μM) with a variety of hydrophobic interactions.

Product information

CAS Number: 2204230-40-8

Molecular Weight: 460.48

Formula: C24H17FN4O3S

Chemical Name: 1-(4-cyanophenyl)-N-(3-fluorophenyl)-3-(4-methanesulfonylphenyl)-1H-pyrazole-4-carboxamide

Smiles: CS(=O)(=O)C1C=CC(=CC=1)C1=NN(C=C1C(=O)NC1=CC(F)=CC=C1)C1C=CC(=CC=1)C#N

InChiKey: ZUWUBCCXJATTTE-UHFFFAOYSA-N

InChi: InChI=1S/C24H17FN4O3S/c1-33(31,32)21-11-7-17(8-12-21)23-22(24(30)27-19-4-2-3-18(25)13-19)15-29(28-23)20-9-5-16(14-26)6-10-20/h2-13,15H,1H3,(H,27,30)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CM121 interacts with the main-chain amides of Cys320 and Thr321 and the side-chains of Thr321 and Asn187 via methylsulfonyl oxygen. CM121 establishes π-π stacking with the side chains of PHE188 and PHE314 through methylsulfonyl benzene and benzylonitrile rings.

Products are for research use only. Not for human use.

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