IL-17A inhibitor 1


Catalog No. Size PriceQuantity
M17786-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

IL-17A inhibitor 1 (example 24) is a IL-17A inhibitor, with IC50 values of <9.45 nM and 9.3 nM in alphalisa assay and HT-29 cells.

Product information

CAS Number: 2452464-73-0

Molecular Weight: 586.51

Formula: C24H27F5N8O4

Chemical Name: N-[(S)-(4, 4-difluorocyclohexyl)({7-[(1S)-2-methoxy-1-[(4S)-2-oxo-4-(trifluoromethyl)imidazolidin-1-yl]ethyl]imidazo[1, 2-b]pyridazin-2-yl})methyl]-4-methyl-1, 2, 5-oxadiazole-3-carboxamide

Smiles: CC1=NON=C1C(=O)N[C@@H](C1CCC(F)(F)CC1)C1=CN2N=CC(=CC2=N1)[C@@H](COC)N1C[C@H](NC1=O)C(F)(F)F

InChiKey: MVWVCLAORBNXSD-UWVAXJGDSA-N

InChi: InChI=1S/C24H27F5N8O4/c1-12-19(35-41-34-12)21(38)33-20(13-3-5-23(25,26)6-4-13)15-9-37-18(31-15)7-14(8-30-37)16(11-40-2)36-10-17(24(27,28)29)32-22(36)39/h7-9,13,16-17,20H,3-6,10-11H2,1-2H3,(H,32,39)(H,33,38)/t16-,17+,20+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

IL-17A inhibitor 1 (example 24) possesses high oral bioavailability (F=107%).

Products are for research use only. Not for human use.

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