PROTAC IRAK4 degrader-3


Catalog No. Size PriceQuantity
M17787-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader.

Product information

CAS Number: 2374122-43-5

Molecular Weight: 1086.28

Formula: C57H68FN11O8S

Chemical Name: 1-{[(2S, 3S, 4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-4-{3-[9-(5-{[(2R)-1-[(2R, 4S)-4-hydroxy-2-({[4-(4-methyl-1, 3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3, 3-dimethyl-1-oxobutan-2-yl]carbamoyl}pyrimidin-2-yl)-3, 9-diazaspiro[5.5]undecan-3-yl]prop-1-yn-1-yl}-7-methoxyisoquinoline-6-carboxamide

Smiles: CC(C)(C)[C@@H](NC(=O)C1=CN=C(N=C1)N1CCC2(CC1)CCN(CC#CC1=CN=C(OC[C@H]3NC(=O)[C@@H](F)[C@H]3CC)C3=CC(OC)=C(C=C31)C(N)=O)CC2)C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NCC1C=CC(=CC=1)C1SC=NC=1C

InChiKey: VCCDOPPWOSIMCD-HCDYCOHBSA-N

InChi: InChI=1S/C57H68FN11O8S/c1-7-39-43(65-52(74)46(39)58)31-77-53-41-25-45(76-6)42(49(59)71)24-40(41)36(27-61-53)9-8-18-67-19-14-57(15-20-67)16-21-68(22-17-57)55-62-28-37(29-63-55)50(72)66-48(56(3,4)5)54(75)69-30-38(70)23-44(69)51(73)60-26-34-10-12-35(13-11-34)47-33(2)64-32-78-47/h10-13,24-25,27-29,32,38-39,43-44,46,48,70H,7,14-23,26,30-31H2,1-6H3,(H2,59,71)(H,60,73)(H,65,74)(H,66,72)/t38-,39-,43+,44+,46-,48-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTAC IRAK4 degrader-3 (0.01~10 μM; 2 hours; PBMCs) mediated degradation is occurring in a proteasome dependent manner. PROTAC IRAK4 degrader-3 (0.01~100 μM; 18 hours; PBMCs) is capable of completely blocking IL-6 secretion.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

You may also like

Recently viewed