Description
AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol.
Product information
CAS Number: 366-93-8
Molecular Weight: 464.30
Formula: C22H30Cl4N2
Chemical Name: [(2-chlorophenyl)methyl]({[4-({[(2-chlorophenyl)methyl]amino}methyl)cyclohexyl]methyl})amine dihydrochloride
Smiles: Cl.Cl.ClC1=CC=CC=C1CNCC1CCC(CNCC2=CC=CC=C2Cl)CC1
InChiKey: NRVIEWRSGDDWHP-UHFFFAOYSA-N
InChi: InChI=1S/C22H28Cl2N2.2ClH/c23-21-7-3-1-5-19(21)15-25-13-17-9-11-18(12-10-17)14-26-16-20-6-2-4-8-22(20)24;;/h1-8,17-18,25-26H,9-16H2;2*1H
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 5 mg/mL (10.77 mM; Need ultrasonic). H2O : 5 mg/mL (10.77 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
Products are for research use only. Not for human use.
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