L791943


Catalog No. Size PriceQuantity
M18012-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

L791943 is a potent, selective Phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 4.2 nM.

Product information

CAS Number: 192767-01-4

Molecular Weight: 573.38

Formula: C24H17F10NO4

Chemical Name: 4-{2-[3,4-bis(difluoromethoxy)phenyl]-2-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]ethyl}-1λ⁵-pyridin-1-one

Smiles: OC(C1C=CC(=CC=1)C(CC1C=CN(=O)=CC=1)C1=CC(OC(F)F)=C(C=C1)OC(F)F)(C(F)(F)F)C(F)(F)F

InChiKey: VIOWRSXFEPSZFI-UHFFFAOYSA-N

InChi: InChI=1S/C24H17F10NO4/c25-20(26)38-18-6-3-15(12-19(18)39-21(27)28)17(11-13-7-9-35(37)10-8-13)14-1-4-16(5-2-14)22(36,23(29,30)31)24(32,33)34/h1-10,12,17,20-21,36H,11H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The extent of metabolism of L791943 is evaluated in vitro in rat hepatocytes and compared to the data obtaine with CDP-840. In our standard incubation conditions, >98% of the parent drug remain in the case of L791943 whereas only 11% of CDP-840 is left intact.

Products are for research use only. Not for human use.

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