OSIP-486823


Catalog No. Size PriceQuantity
M18022-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

OSIP-486823 is a novel microtubule-interfering agent with distinct biological effects on both protein kinase G (PKG) and microtubules.

Product information

CAS Number: 200803-37-8

Molecular Weight: 473.54

Formula: C29H28FNO4

Chemical Name: N-benzyl-2-[(1Z)-5-fluoro-2-methyl-1-[(3,4,5-trimethoxyphenyl)methylidene]-1H-inden-3-yl]acetamide

Smiles: CC1/C(=C/C2C=C(OC)C(OC)=C(C=2)OC)/C2C=CC(F)=CC=2C=1CC(=O)NCC1C=CC=CC=1

InChiKey: KATLSKIJHJJAEB-FMCGGJTJSA-N

InChi: InChI=1S/C29H28FNO4/c1-18-23(12-20-13-26(33-2)29(35-4)27(14-20)34-3)22-11-10-21(30)15-25(22)24(18)16-28(32)31-17-19-8-6-5-7-9-19/h5-15H,16-17H2,1-4H3,(H,31,32)/b23-12-

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

OSIP486823 inhibits growth and induce apoptosis in SW480 human colon cancer cells, with IC50 of 0.1 μM. OSIP-486823 (OSIP486823) causes depolymerization of microtubules in interphase cells, inhibit spindle formation in mitotic cells, and induce multinucleated cells. Exisulind and the potent synthetic derivative OSIP-486823 are members of a new class of drugs known as selective apoptotic antineoplastic drugs that target cyclic guanosine 3′,5′-monophosphate phosphodiesterases (cGMP-PDE). OSIP-486823 also disrupts microtubule polymerization, perturbs mitotic spindle function, and arrests cells in mitosis in human glioma cells.

Products are for research use only. Not for human use.

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