SBI-115


Catalog No. Size PriceQuantity
M18033-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.

Product information

CAS Number: 882366-16-7

Molecular Weight: 340.78

Formula: C14H13ClN2O4S

Chemical Name: 3-methylphenyl 5-chloro-2-(ethanesulfonyl)pyrimidine-4-carboxylate

Smiles: CC1C=CC=C(C=1)OC(=O)C1=NC(=NC=C1Cl)S(=O)(=O)CC

InChiKey: IJPXOPBVXVPPEW-UHFFFAOYSA-N

InChi: InChI=1S/C14H13ClN2O4S/c1-3-22(19,20)14-16-8-11(15)12(17-14)13(18)21-10-6-4-5-9(2)7-10/h4-8H,3H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 150 mg/mL (440.17 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SBI-115 (100-200 µM, 24 hours) inhibits proliferation triggered by pre-treatment of cystic cholangiocytes with Taurolithocholic acid (TLCA) in shRNA-transfected ADPKD cholangiocytes.

Products are for research use only. Not for human use.

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