7-Chlorokynurenic acid sodium salt


Catalog No. Size PriceQuantity
M18164-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

7-Chlorokynurenic acid sodium salt (7-CKA sodium salt) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery.

Product information

CAS Number: 1263094-00-3

Molecular Weight: 245.59

Formula: C10H5ClNNaO3

Chemical Name: sodium 7-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylate

Smiles: [Na+].[O-]C(=O)C1=CC(=O)C2C=CC(Cl)=CC=2N1

InChiKey: IFZYIORLNGNLEI-UHFFFAOYSA-M

InChi: InChI=1S/C10H6ClNO3.Na/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13;/h1-4H,(H,12,13)(H,14,15);/q;+1/p-1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 33.67 mg/mL (137.10 mM). H2O : 50 mg/mL (203.59 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid sodium salt (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.

Products are for research use only. Not for human use.

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