Hemopressin (human, mouse)

Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts antinociceptive action in inflammatory pain models.

Product information

CAS Number: 1314035-51-2

Molecular Weight: 1054.24

Formula: C50H79N13O12

Chemical Name: (2S)-2-[(Z)-[(2S)-2-[(Z)-[(2S)-2-[(Z)-[(2S)-2-[(Z)-[(2S)-6-amino-1-hydroxy-2-[(Z)-[(2S)-1-hydroxy-2-[(Z)-[(2S)-1-hydroxy-2-[(Z)-[(2S)-1-hydroxy-2-[(Z)-{hydroxy[(2S)-pyrrolidin-2-yl]methylidene}amino]-3-methylbutylidene]amino]-3-(C-hydroxycarbonimidoyl)propylidene]amino]-3-phenylpropylidene]amino]hexylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-1,3-dihydroxypropylidene]amino]-3-(1H-imidazol-5-yl)propanoic acid

Smiles: CC(C)[C@H](/N=C(\O)/[C@@H]1CCCN1)/C(/O)=N/[C@@H](CC(=N)O)/C(/O)=N/[C@@H](CC1C=CC=CC=1)/C(/O)=N/[C@@H](CCCCN)/C(/O)=N/[C@@H](CC(C)C)/C(/O)=N/[C@@H](CC(C)C)/C(/O)=N/[C@@H](CO)/C(/O)=N/[C@@H](CC1=CN=CN1)C(O)=O

InChiKey: JEXQOFXDPAGOQL-TZFLQVIRSA-N

InChi: InChI=1S/C50H79N13O12/c1-27(2)19-34(44(68)58-35(20-28(3)4)45(69)62-39(25-64)48(72)61-38(50(74)75)22-31-24-53-26-55-31)57-43(67)33(15-10-11-17-51)56-46(70)36(21-30-13-8-7-9-14-30)59-47(71)37(23-40(52)65)60-49(73)41(29(5)6)63-42(66)32-16-12-18-54-32/h7-9,13-14,24,26-29,32-39,41,54,64H,10-12,15-23,25,51H2,1-6H3,(H2,52,65)(H,53,55)(H,56,70)(H,57,67)(H,58,68)(H,59,71)(H,60,73)(H,61,72)(H,62,69)(H,63,66)(H,74,75)/t32-,33-,34-,35-,36-,37-,38-,39-,41-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE). Oral administration of Hemopressin inhibits mechanical hyperalgesia of CCI-rats up to 6h. Hemopressin treatment also decreases Egr-1 immunoreactivity (Egr-1Ir) in the superficial layer of the dorsal horn of the spinal cord of CCI rats.

Products are for research use only. Not for human use.