ML133 hydrochloride


Catalog No. Size PriceQuantity
M18247-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.

Product information

CAS Number: 1222781-70-5

Molecular Weight: 313.82

Formula: C19H20ClNO

Chemical Name: [(4-methoxyphenyl)methyl][(naphthalen-1-yl)methyl]amine hydrochloride

Smiles: Cl.COC1C=CC(CNCC2=CC=CC3=CC=CC=C23)=CC=1

InChiKey: NGQIBUUFXDPHKT-UHFFFAOYSA-N

InChi: InChI=1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 125 mg/mL (398.32 mM). H2O : < 0.1 mg/mL (insoluble).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ML133, which inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5, but exhibits little selectivity against other members of Kir2.x family channels. ML133 has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date.

Products are for research use only. Not for human use.

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