SCH28080


Catalog No. Size PriceQuantity
M18425-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

SCH28080 is a reversible, K+-competitive inhibitor of the gastric H,K-ATPase, with a Ki of 0.12 μM. SCH28080 is an effective inhibitor of acid secretion in vivo and with anti-gastric ulcer activity.

Product information

CAS Number: 76081-98-6

Molecular Weight: 277.32

Formula: C17H15N3O

Chemical Name: 2-[8-(benzyloxy)-2-methylimidazo[1,2-a]pyridin-3-yl]acetonitrile

Smiles: CC1N=C2C(=CC=CN2C=1CC#N)OCC1C=CC=CC=1

InChiKey: PYKJFEPAUKAXNN-UHFFFAOYSA-N

InChi: InChI=1S/C17H15N3O/c1-13-15(9-10-18)20-11-5-8-16(17(20)19-13)21-12-14-6-3-2-4-7-14/h2-8,11H,9,12H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (360.59 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

SCH28080 competitively inhibits the K+-stimulated hydrolysis of ATP, with a Ki of 0.12 μM . SCH28080 inhibits histamine-induced [14C]aminopyrine uptake into isolated rabbit parietal cells with an IC50 of 0.029 μM. SCH28080 causes a dose-dependent reduction in cell viability with IC50 values of 22.9 µM and 15.3 µM after 2 h and 24 h treatments, respectively, and cell viability was below 10% at 100 µM already after 2 h treatment. SCH28080 induces apoptosis and is cytotoxic at higher doses. SCH28080 inhibits insulin secretion by activation of IK ATP and inhibition of L-type voltage-gated Ca2+ channels, reduces cell viability and dose-dependently induces apoptosis/necrosis.

In Vivo:

SCH28080 (20 mg/kg; i.p.) inhibits gastric ulcers induced by pylorusligation in rats.

Products are for research use only. Not for human use.

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