Description
RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
Product information
CAS Number: 876310-60-0
Molecular Weight: 482.62
Formula: C26H38N6O3
Chemical Name: (Z,2S)-5-carbamimidamido-2-[(Z)-{hydroxy[(3R,5S,7s)-adamantan-1-yl]methylidene}amino]-N-[(1S)-1-(C-hydroxycarbonimidoyl)-2-phenylethyl]pentanimidic acid
Smiles: NC(=N)NCCC[C@H](/N=C(\O)/C12C[C@@H]3C[C@H](C1)C[C@H](C2)C3)/C(/O)=N/[C@@H](CC1C=CC=CC=1)C(=N)O
InChiKey: UMKHUSRDQFQHAK-XIXLPFSXSA-N
InChi: InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17-,18+,19-,20-,21-,26?/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 125 mg/mL (259.00 mM; Need ultrasonic). H2O : 16.67 mg/mL (34.54 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
RF9 (10 μM) pretrement completely blocks NPFF induced neurite outgrowth of Neuro 2A cells.
In Vivo:
RF9 (0.1 mg/kg, s.c. ) with heroin coadministration prevents heroin-induced delayed hyperalgesia and tolerance. RF9 (10 μg) infused alone does not result in a significant alteration of MAP or heart rate. Conversely, MAP and heart rate increases evoked by NPFF are significantly blocked when NPFF is applied in conjunction with RF9.
Products are for research use only. Not for human use.
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