Description
Choline bitartrate is a vitamin-like essential nutrient, can affect diseases such as liver disease, atherosclerosis and neurological disorders. Choline bitartrate is a precursor for the neurotransmitter acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.
Product information
CAS Number: 87-67-2
Molecular Weight: 253.25
Formula: C9H19NO7
Chemical Name: (2-hydroxyethyl)trimethylazanium (2R,3R)-3-carboxy-2,3-dihydroxypropanoate
Smiles: C[N+](C)(C)CCO.[O-]C(=O)[C@H](O)[C@@H](O)C(O)=O
InChiKey: QWJSAWXRUVVRLH-LREBCSMRSA-M
InChi: InChI=1S/C5H14NO.C4H6O6/c1-6(2,3)4-5-7;5-1(3(7)8)2(6)4(9)10/h7H,4-5H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)/q+1;/p-1/t;1-,2-/m.1/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 55 mg/mL (217.18 mM; Need ultrasonic). H2O : 120 mg/mL (473.84 mM; Need ultrasonic).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Choline serves as a precursor component to two major cell membrane components: phosphatidylcholine and sphingomyelin in vitro. Choline is also a major source for methyl groups via its metabolite, betaine, which participates in S-adenosylmethionine synthesis pathways.
In Vivo:
Choline bitartrate (oral gavage; 300 mg/kg vs. 5 g/kg) is administrated. Choline restriction (300 mg/kg) provokes robust ketosis and weight loss in mice, also causes significant hepatic steatosis, inflammation, and cellular injury. when Choline is repleted, moderate ketosis and hepatic fat accumulation can be attenuated.
Products are for research use only. Not for human use.
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