AC-264613


Catalog No. Size PriceQuantity
M18723-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

AC-264613 is a potent and selective protease-activated receptor (PAR-2) agonist with a pEC50 of 7.5.

Product information

CAS Number: 1051487-82-1

Molecular Weight: 400.27

Formula: C19H18BrN3O2

Chemical Name: N'-[1-(3-bromophenyl)ethylidene]-2-oxo-4-phenylpyrrolidine-3-carbohydrazide

Smiles: CC(=NNC(=O)C1C(CNC1=O)C1C=CC=CC=1)C1=CC(Br)=CC=C1

InChiKey: RQKXQCSEZPQBNZ-WSDLNYQXSA-N

InChi: InChI=1S/C19H18BrN3O2/c1-12(14-8-5-9-15(20)10-14)22-23-19(25)17-16(11-21-18(17)24)13-6-3-2-4-7-13/h2-10,16-17H,11H2,1H3,(H,21,24)(H,23,25)/b22-12+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

AC-264613 (10 μM; for 6 hours) causes a decrease of IRF5 expression and also significantly reduces p53 protein expression in macrophages.

In Vivo:

AC-264613 exhibits moderate elimination half-live (T1/2=2.5±2.0 h) following i.p. administration (10 mg/kg) in male Sprague-Dawley rats.

Products are for research use only. Not for human use.

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