Description
Halopemide is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent.
Product information
CAS Number: 59831-65-1
Molecular Weight: 416.88
Formula: C21H22ClFN4O2
Chemical Name: N-{2-[4-(5-chloro-2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)piperidin-1-yl]ethyl}-4-fluorobenzamide
Smiles: O=C1NC2C=C(Cl)C=CC=2N1C1CCN(CCNC(=O)C2C=CC(F)=CC=2)CC1
InChiKey: NBHPRWLFLUBAIE-UHFFFAOYSA-N
InChi: InChI=1S/C21H22ClFN4O2/c22-15-3-6-19-18(13-15)25-21(29)27(19)17-7-10-26(11-8-17)12-9-24-20(28)14-1-4-16(23)5-2-14/h1-6,13,17H,7-12H2,(H,24,28)(H,25,29)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Halopemide (1-2 μM; 21 day) affects calcification in transdifferentiated MOVAS cells.
In Vivo:
Halopemide (10 mg/kg; p.o.) induces dyskinesias in the majority of monkeys tested.
Products are for research use only. Not for human use.
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