CL-82198


Catalog No. Size PriceQuantity
M18784-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression.

Product information

CAS Number: 307002-71-7

Molecular Weight: 338.83

Formula: C17H23ClN2O3

Chemical Name: N-[4-(morpholin-4-yl)butyl]-1-benzofuran-2-carboxamide hydrochloride

Smiles: Cl.O=C(NCCCCN1CCOCC1)C1=CC2=CC=CC=C2O1

InChiKey: PIOACXKZWXHBRB-UHFFFAOYSA-N

InChi: InChI=1S/C17H22N2O3.ClH/c20-17(16-13-14-5-1-2-6-15(14)22-16)18-7-3-4-8-19-9-11-21-12-10-19;/h1-2,5-6,13H,3-4,7-12H2,(H,18,20);1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (330.72 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

CL-82198 (10 μM; 24 hours) significantly reduces LS174 cell migration. CL-82198 decreases CTGF and TGF-β1 protein levels in hepatic stellate cells.

In Vivo:

CL82198 (1-10 mg/kg; i.p.; every other day for 12 weeks) prevents and decelerates MLI-induced osteoarthritis progression.

Products are for research use only. Not for human use.

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