Firuglipel


Catalog No. Size PriceQuantity
M18807-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Firuglipel (DS-8500a) is an orally available, potent and selective GPR119 agonist.

Product information

CAS Number: 1371591-51-3

Molecular Weight: 467.49

Formula: C25H26FN3O5

Chemical Name: 4-{5-[(1R)-1-(4-cyclopropanecarbonylphenoxy)propyl]-1,2,4-oxadiazol-3-yl}-2-fluoro-N-[(2R)-1-hydroxypropan-2-yl]benzamide

Smiles: C[C@H](CO)NC(=O)C1C=CC(=CC=1F)C1N=C(ON=1)[C@@H](CC)OC1C=CC(=CC=1)C(=O)C1CC1

InChiKey: LRXRIKVDAVVQCP-SPLOXXLWSA-N

InChi: InChI=1S/C25H26FN3O5/c1-3-21(33-18-9-6-16(7-10-18)22(31)15-4-5-15)25-28-23(29-34-25)17-8-11-19(20(26)12-17)24(32)27-14(2)13-30/h6-12,14-15,21,30H,3-5,13H2,1-2H3,(H,27,32)/t14-,21-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Firuglipel (DS-8500a) increases intracellular cAMP in a concentration-dependent manner in human, rat, and mouse GPR119-expressing Chinese hamster ovary (CHO)-K1 cells, with EC50 values of 51.5, 98.4, and 108.1 nM, respectively. DS-8500a has no effect on intracellular cAMP in pcDNA3.1/CHO-K1 cells.

In Vivo:

Firuglipel (DS-8500a) (1-30 mg/kg) upregulates glucagon-like peptide-1 and enhances glucose-dependent insulin secretion and improves glucose homeostasis in type 2 diabetic rats.

Products are for research use only. Not for human use.

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