Cipralisant


Catalog No. Size PriceQuantity
M18900-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Cipralisant is a potent and selective histamine H3 receptor antagonist in vivo, and an agonist in vitro, with a pKi of 9.9 for histamine H3 receptor and a Ki of 0.47 nM for rat histamine H3 receptor; Cipralisant has the potential for attention-deficit hyperactivity disorder treatment.

Product information

CAS Number: 213027-19-1

Molecular Weight: 216.32

Formula: C14H20N2

Chemical Name: 5-[(1R,2R)-2-(5,5-dimethylhex-1-yn-1-yl)cyclopropyl]-1H-imidazole

Smiles: CC(C)(C)CCC#C[C@@H]1C[C@H]1C1=CN=CN1

InChiKey: CVKJAXCQPFOAIN-VXGBXAGGSA-N

InChi: InChI=1S/C14H20N2/c1-14(2,3)7-5-4-6-11-8-12(11)13-9-15-10-16-13/h9-12H,5,7-8H2,1-3H3,(H,15,16)/t11-,12-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Cipralisant (GT-2331) is a potent histamine H3 receptor antagonist with a pKi of 9.9 and a Ki of 0.47 nM for rat histamine H3 receptor. Cipralisant acts as a full agonist at the recombinant rat histamine H3 receptor in vitro, and potently inhibits forskolin-induced cAMP accumulation with an EC50 of 0.23 nM. Cipralisant increases the basal [35S]GTPγS binding activities in membranes from HEK cells expressing the rat histamine H3 receptor (EC50, 5.6 nM).

In Vivo:

Cipralisant (GT-2331) acts as an antagonist of histamine H3 receptor, and blocks R-α-methylhistamine (a histamine H3 receptor agonist)-induced water intake at 10 mg/kg via oral administration in rats.

Products are for research use only. Not for human use.

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