Resorcinolnaphthalein


Catalog No. Size PriceQuantity
M19023-C Contact sales@xcessbio.com for quotation $100Unavailable

Description

Resorcinolnaphthalein is a specific angiotensin-converting enzyme 2 (ACE2) enhancer and activates ACE2 activity with an EC50 value of 19.5 μM. Resorcinolnaphthalein can be used for the investigation of hypertension and renal fibrosis.

Product information

CAS Number: 41307-63-5

Molecular Weight: 382.36

Formula: C24H14O5

Chemical Name: 3',6'-dihydroxy-3-oxaspiro[tricyclo[7.3.1.0⁵,¹³]tridecane-2,9'-xanthene]-1(13),5,7,9,11-pentaen-4-one

Smiles: OC1C=C2OC3C=C(O)C=CC=3C3(OC(=O)C4=CC=CC5=CC=CC3=C54)C2=CC=1

InChiKey: FTUOFHGOGJGQAB-UHFFFAOYSA-N

InChi: InChI=1S/C24H14O5/c25-14-7-9-17-20(11-14)28-21-12-15(26)8-10-18(21)24(17)19-6-2-4-13-3-1-5-16(22(13)19)23(27)29-24/h1-12,25-26H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (326.92 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Resorcinolnaphthalein (100 μM) and XNT enhances ACE2 activity in a dose-dependent manner with EC50 values of 19.5 μM and 20.1 μM, respectively. ACE2 is an effective enzyme in attenuating fibrosis and structural remodeling. Enhancement of ACE2 activity has beneficial effects on the cardiovascular system and protects against hypertension induced pathophysiology.

Products are for research use only. Not for human use.

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